Purpose: To determine the pattern of presentation and clinical profile of patients with rubeosis iridis in a developing country. Setting: The study was carried out in the department of ophthalmology, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, Nigeria. Methods: The case records of all patients who presented with features of rubeosis iridis to the department of ophthalmology from January 2013 to December 2017 were retrieved. Data collected included, age, sex, diagnosis, presenting visual acuity, presenting intraocular pressure, presence of angle neovascularization, presence of hyphaema. Results were analysed using Statistical Package for Social Sciences ( SPSS) 22.0 for Windows statistical software Results: Twenty- four eyes of twenty patients were studied. Four patients had bilateral disease. The mean age=55.92±12.91 years, with an equal sex distribution. The commonest aetiological factors seen were Proliferative diabetic retinopathy, in 10 (42%) eyes and retinal vein occlusion10(42%) eyes. Three patients (12%) had retinal detachment and 1 patient (4%) had chronic uveitis. Most patients presented with severe visual impairment (V/A < 6/60) and intraocular pressures between 21-45mmHg. There was a statistically significant difference between the stage of presentation and the intraocular pressure at presentation- p= 0.000. Seventeen (70.8%) patients had hyphaema. Medical treatment with intraocular pressure lowering medications used in combination with intravitreal Anti Vascular endothelial growth factors was the commonest modality of treatment employed, used in 9(37.5%) eyes Conclusions: The pattern of presentation and Rubeosis iridis in the developing country mirrors that reported in other countries to a great extent with proliferative diabetic retinopathy and retinal vein occlusion as the major aetiological factors. However the late stage at presentation appears to be peculiar in our clime. More awareness needs to be created in these risk groups to enhance early detection and prompt intervention to prevent visual loss.