Introduction: Prostatic disease is a common presentation in our environment with a wide range of histomorphological patterns and a diverse range of Prostatic Specific Antigen (PSA) values. Correlation of the histomorphological patterns with PSA would enable a baseline data for which clinicians can manage patients effectively Methodology: This was a retrospective cross-sectional study of 2 years duration including the retrieval and analysis of tissue blocks. Results: A total of 251 prostate biopsies were received during the study period however only 197 (78.5%) biopsies fulfilled the inclusion criteria for this study. The age range of participants was from 46 – 91 years. From the study population, 2% had PSA values within the normal range of ≤4ng/ml while 98% had ≥4ng/ml. Malignant lesions constituted 57.4% of the population and all had a diagnosis of adenocarcinoma. Benign prostatic hyperplasia was the second most common lesion accounting for 21.8%. More than half of the patients with PSA from 11ng/ml to 100ng/ml were diagnosed with cancer. At values ≥100ng/ml, 52% of the cases had a diagnosis of CAP. Conclusion: This study concludes that PSA findings cannot predict the histological grade of prostate cancer but can predict the likelihood of a prostatic disease being cancerous. Prostatic biopsies should be done for all patients for proper grading of the prostatic adenocarcinoma which has prognostic value.