Introduction: Human papillomavirus (HPV) is a prerequisite for cervical cancer accounting for about 99% of cervical cancer cases as attributed by the world health organization. HPV vaccination and screening for cervical cancer are two important measures to reduce the burden of the disease however the populace needs to be aware and understand such interventions for uptake to be optimal. Materials and methods: This was a primary study with a cross-sectional design utilizing a house-to-house survey and an interviewer-administered questionnaire. The sample size was 390 drawn by multistage cluster sampling from adults aged 18-49 years of age. Results: Among the participants 24.1% had heard of cervical cancer while 11% were aware of HPV. Also 8.46% were aware of an HPV vaccine of which 57.6% confirmed the health workers as their source of information. Acceptance of the vaccine was 97.7%. Vaccine uptake was 0.26%, and the most common reason for the lack of acceptance and uptake was insufficient knowledge. The price of the vaccine (42.5%) closely followed by not knowing where to get/buy the vaccine from (31.4%) were the most common barriers to the uptake of the vaccine. Conclusion: The awareness of cervical cancer, HPV and HPV vaccine is very low in Kogi state; however the acceptability of the vaccine is high and the population is receptive to new knowledge. Keywords: Human papillomavirus, Cervical cancer, PAP smear, Vaccine