Background: In vitro fertilization technique is one of the many assisted conception treatment options that has helped to reduce the burden of infertility in over two decades. Pregnancies resulting from IVF are noticed to have more burdens of morbidities than pregnancies that are naturally conceived. Objectives: To evaluate the fetomaternal outcome of pregnancies conceived from invitro fertilization and were managed and delivered at the University of Port Harcourt Teaching Hospital (UPTH). Materials and Methods: This was a 5-year retrospective study of all pregnant women who had conceived via in vitro fertilization, assisted conception and had obstetric care at the University of Port Harcourt Teaching Hospital (UPTH). The Statistical package Microsoft excel 2019 was used for analysis of data from patients case records. Results: The incidence of deliveries from IVF pregnancy was 0.67%. There were 24(52.17%) multiple pregnancies resulting from IVF deliveries and 14 (30.43%) were twin deliveries. Among the patients 7(13.04%) had severe pre-eclampsia and 3(6.25%) each had gestational diabetes mellitus and primary post-partum haemorrhage respectively. There was a 100% caesarean section rate and 34.78% of the women had their neonates admitted in the special care baby units. Conclusion: In vitro fertilization pregnancies are associated with increased risk for caesarean section, adverse maternal and neonatal outcomes due to increase in fetomaternal morbidities. Keywords: Invitro fertilization pregnancy, maternal outcome, fetal outcome, Port Harcourt.